Try use the Process.Start() method. Code Snippet Sub Button2_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button2.Click Process.Start("C:\\1.exe") End Sub
Sub Button2_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button2.Click
Process.Start("C:\\1.exe")
End Sub