Hi!
I seen a lot alike in VS.NET 2003. Controls may jump somewhere away from form and so on. Mostly it happens because of invalid source code while opening designer (it works fine with correct C# syntax only). And sometimes it even tries to delete my controls.
In 2005 I not seen things like this yet, but notice that in designer ToolStip hidden buttons visible only when strip focused, it makes a little confusion.
Another problem with designer I seen in 2005 is when you have binding navigator and name some button on it DeleteItem (just like navigator's property). All compiled and started and worked. But next time I open designer - it fails to open.
All I can suggest here isto check in source code coordinates of this controls. Perhabs they are offscreen?