If you use a tableAdapter, you may try this
this.Validate();
this.customersBindingSource.EndEdit();
this.customersTableAdapter.Update(this.northwindDataSet.Customers);
Or sometinglike this
cm =(CurrencyManager)this.BindingContext[northwindDataSet,"Customers"];
northwindDataSet is a dataset while "customers" is table in it.
Please tell me whether they work or not.