I've done it. Here are results:
100,00% SetDefaultDomainManager - 4852,9 ms - 1 call - System.AppDomain.SetDefaultDomainManager(String, String [], String [])
99,96% SetDomainManager - 4850,9 ms - 1 call - System.AppDomain.SetDomainManager(Evidence, Evidence, IntPtr, Boolean)
50,04% SetupApplicationHelper - 2428,3 ms - 1 call - System.AppDomain.SetupApplicationHelper(Evidence, Evidence, ApplicationIdentity, ActivationContext, String [])
47,78% CreateActivationContext - 2318,6 ms - 1 call - System.Deployment.Internal.Isolation.Manifest.CmsUtils.CreateActivationContext(String, String [], Boolean, ApplicationIdentity &, ActivationContext &)
1,05% MergeApplicationEvidence - 51,0 ms - 1 call - System.Deployment.Internal.Isolation.Manifest.CmsUtils.MergeApplicationEvidence(Evidence, ApplicationIdentity, ActivationContext, String [], ApplicationTrust)
0,00% get_ActivationArguments - 0,0 ms - 5 calls - System.AppDomainSetup.get_ActivationArguments()
0,00% get_ApplicationTrust - 0,0 ms - 1 call - System.AppDomainSetup.get_ApplicationTrust()
0,00% get_UseFusionActivationContext - 0,0 ms - 1 call - System.Runtime.Hosting.ActivationArguments.get_UseFusionActivationContext()
0,00% get_ApplicationFullName - 0,0 ms - 1 call - System.Runtime.Hosting.ActivationArguments.get_ApplicationFullName()
0,00% get_ActivationData - 0,0 ms - 1 call - System.Runtime.Hosting.ActivationArguments.get_ActivationData()
0,00% get_FusionStore - 0,0 ms - 1 call - System.AppDomain.get_FusionStore()
0,00% get_ApplicationManifestPaths - 0,0 ms - 1 call - System.Runtime.Hosting.ActivationArguments.get_ApplicationManifestPaths()
0,00% set_ActivationArguments - 0,0 ms - 1 call - System.AppDomainSetup.set_ActivationArguments(ActivationArguments)
0,00% ActivationArguments..ctor - 0,0 ms - 1 call - System.Runtime.Hosting.ActivationArguments..ctor(String, String [], String [])
0,00% get_FusionStore - 0,0 ms - 1 call - System.AppDomain.get_FusionStore()
Application run from exe file:
100,00% SetDefaultDomainManager - 3,1972 ms - 1 call - System.AppDomain.SetDefaultDomainManager(String, String [], String [])
57,10% SetDomainManager - 1,8255 ms - 1 call - System.AppDomain.SetDomainManager(Evidence, Evidence, IntPtr, Boolean)
11,08% PermissionSet..cctor - 0,3542 ms - 1 call - System.Security.PermissionSet..cctor()
0,01% PermissionSet..ctor - 0,0002 ms - 1 call - System.Security.PermissionSet..ctor(Boolean)
0,00% get_ApplicationTrust - 0,0000 ms - 1 call - System.AppDomainSetup.get_ApplicationTrust()
0,00% get_ActivationArguments - 0,0000 ms - 1 call - System.AppDomainSetup.get_ActivationArguments()
0,00% get_FusionStore - 0,0000 ms - 1 call - System.AppDomain.get_FusionStore()
As you can see there is no call for following methods:
SetupApplicationHelper
CreateActivationContext