We are rolling out the new release of an application using the ClickOnce deployment paradigm. For the majority of our customers, it's an excellent fit, and we've had relatively few problems so far. However, we have one customer that would like to deploy the application to a Citrix Metaframeserver farm with two servers and roaming profiles enabled. The IT administrator there installed the application from within install mode, first from an administrative account and then from a user account. In both cases, when he tried to log in remotely and run the application reference file from the Start Menu, he received the following error message,:

"<application> failed to start. The Citrix server is unable to process your request to start this published application. Please try again. If the problem persists, contact your administrator."

It may beworth noting that <application> was actually only the first word of three in the name of the application.

Any thoughts/suggestions?

I've cross-posted this question to a Citrix forum as well; it's getting a little activity there. I'll update the MSDN thread if we find some answers over there.