Has anyone seen this before?:

I deployed my VB2005 app to a server using click-once publishing, and the app runs quite nicely on it. I later decided to move to a setup program so that I can give more install options to the user. After creating the setup program, I copied the entire "release" folder to the server, ran the install without error, but now my app won't execute - no fatal errors or any indication of a problem. Basically, double-clicking the app's icon appears to do nothing.

If I am missing assemblies, I would expect to see an error of some kind. Any ideas?