Hi Derek,
When installing a ClickOnce application on a client machine, the user doesn't need to have the local admin rights.
Perhaps the current user's ClickOnce cache on the problematic machine is corrupt. Please have a try deleting the ClickOnce cache of the current user on the problematic machine to see if the problem can be fixed.
If you're using Windows XP, the ClickOnce cache is like below:
c:\Documents and Settings\username\Local Settings\Apps\2.0
If you're using Windows Vista, the ClickOnce cache is as follows:
c:\users\username\AppData\Local\Apps\2.0
Hope this helps.
Sincerely,
Linda Liu
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